Mackenzie, who was originally set to contest three WorldSBK wildcards in 2022, had to withdraw from the Dutch round in Assen due to injuries sustained during pre-season testing.
Since undergoing successful surgery on a broken right ankle, Mackenzie has been back in action in the last two BSB rounds, where he earned a best sixth at Donington Park.
“I am very excited to finally make my Superbike World Championship debut at Donington,” said Mackenzie.
“I feel like it’s been a long time and obviously I was disappointed when we couldn’t do Assen.
“Donington is a special track for me as it’s only 10 minutes from my home, I had great success there at BSB so I can’t wait to get out there on a World Superbike-spec R1 and to see what myself and the McAMS Yamaha team can achieve.
“Obviously there is a lot to learn with the engine and the electronics, but I know the chassis well because my BSB bike is very similar. The level in the World Championship is really high and I can’t wait to get started on the track and giving is our everything.
“I have to say a big thank you to Steve and the McAMS Yamaha team, as well as Andrea and everyone at Yamaha Racing for making this possible.
A consistent challenger in 2020, Mackenzie really found his winning form in 2021 as he won 10 times.
A brilliant showdown performance was enough for Mackenzie to overhaul teammate Jason O’Halloran, and with that claim of a first BSB title 25 years after his father, Niall Mackenzie accomplished the same feat.
Mackenzie will be hoping his first World Championship appearance can be a dress rehearsal for 2023 as he tries to make the move to WorldSBK permanently.
Speaking about Mackenzie’s WorldSBK debut, Andre Dosoli, Yamaha Motor Europe Road Racing Manager added: “We look forward to supporting Tarran and the McAMS Yamaha team as they make their WorldSBK debut with a wildcard appearance at Donington, after what has been an incredibly successful 2021 season for them in the British Superbike Championship.
“We have had a long and successful working relationship with the McAMS team and their two riders, with a true two-way collaboration that benefits everyone.
“We are delighted to see Tarran and McAMS take to the world stage at Donington as it fits perfectly with Yamaha’s racing philosophy of providing opportunities for the best riders and teams in the world.”